Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives

Journal of the Brazilian Chemical Society

Muhammad Hanif²  Muhammad Saleem²  Muhammad Tahir Hussain¹  Nasim Hasan Rama²  Sumera Zaib¹  Muhammad Adil M. Aslam¹  Peter G. Jones¹  Jamshed Iqbal¹ 

[1] ,Quaid-i-Azam University Department of Chemistry Islamabad,Pakistan

关键词: amino-1;    2;    4-triazoles;    triazolothiadiazoles;    urease inhibitors;    antioxidants;    antibacterial activity;   

DOI  :  10.1590/S0103-50532012000500010

来源: SciELO

【 摘 要 】

A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl- and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles. The structures of the synthesized compounds were characterized by infrared (IR), ¹H and 13C nuclear magnetic resonance (NMR), elemental analysis and mass spectrometric (MS) studies. All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to the standard drug.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License