Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

Molecules

Li-Xue Zhang¹  An-Jiang Zhang²  Xian-Xing Chen²  Xin-Xiang Lei²  Xiang-Yun Nan²  Dong-Yong Chen² 

[1] Department of Chemistry, Wenzhou Normal College, Wenzhou 325003, P.R. China.

关键词: Furan ring;    triazolothiadiazoles;    synthesis;    spectral characterization;    biological activity;   

DOI  :  10.3390/70800681

来源: mdpi

【 摘 要 】

3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazoles (2). The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR, ¹H-NMR, ¹³C-NMR and mass spectra. The bioassay indicated most of the title compounds possess significant growth promoting effects on mung bean radicles.

【 授权许可】

Unknown   
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