期刊论文详细信息
Heterocyclic communications
Synthesis and anticancer activities of 1,4-bis(6-aryl-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-3-yl)benzene derivatives
article
Hao-Yu Ding1  De-Jiang Li1 
[1] Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University
关键词: anticancer activity;    synthesis;    triazolothiadiazoles;   
DOI  :  10.1515/hc.2011.015
学科分类:内科医学
来源: De Gruyter
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【 摘 要 】

1,4-Bis(6-aryl-1,2,4-triazolo[3,4- b ]-[1,3,4]thiadiazol-3-yl)­benzenes ( 3 ) were synthesized in high yields by reaction of bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene ( 1 ) with carboxylic acids 2 in the presence of POCl 3 and tetrabutylammonium iodide as catalyst. The MTT assay indicated that compounds 3a–i possess inhibitory activity against the proliferation of HepG-2 (liver cancer), A549-1 (lung cancer) and 231-2 (breast cancer).

【 授权许可】

CC BY|CC BY-NC-ND   

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