期刊论文详细信息
Heterocyclic communications | |
Synthesis and anticancer activities of 1,4-bis(6-aryl-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-3-yl)benzene derivatives | |
article | |
Hao-Yu Ding1 De-Jiang Li1 | |
[1] Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University | |
关键词: anticancer activity; synthesis; triazolothiadiazoles; | |
DOI : 10.1515/hc.2011.015 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
1,4-Bis(6-aryl-1,2,4-triazolo[3,4- b ]-[1,3,4]thiadiazol-3-yl)benzenes ( 3 ) were synthesized in high yields by reaction of bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene ( 1 ) with carboxylic acids 2 in the presence of POCl 3 and tetrabutylammonium iodide as catalyst. The MTT assay indicated that compounds 3a–i possess inhibitory activity against the proliferation of HepG-2 (liver cancer), A549-1 (lung cancer) and 231-2 (breast cancer).
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
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RO202107200002691ZK.pdf | 101KB | download |