Journal of the Brazilian Chemical Society | |
Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety | |
Isis M. Figueiredo2  Luciane V. Dos Santos2  Willian F. Da Costa2  João E. De Carvalho1  Cleuza C. Da Silva2  Juliana L. Sacoman1  Luciana K. Kohn1  Maria H. Sarragiotto2  | |
[1] ,Universidade Estadual de Maringá Departamento de Química Maringá PR ,Brazil | |
关键词: limonene derivatives; thioureas; antiproliferative activity; | |
DOI : 10.1590/S0103-50532006000500020 | |
来源: SciELO | |
【 摘 要 】
A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12 and 16 were the most active with GI50 values in the range of 0.41 to 3.0 µmol L-1, against different cell lines.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202005130105265ZK.pdf | 169KB | download |