Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

Journal of the Brazilian Chemical Society

Kohn, Luciana K.¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Universidade Estadual de Maringá, Maringá, Brazil¹  Silva, Cleuza C. da¹  Sarragiotto, Maria H.¹  Figueiredo, Isis M.¹  Costa, Willian F. da¹  Santos, Luciane V. dos¹  Carvalho, João E. de¹  Sacoman, Juliana L.¹ 

关键词: limonene derivatives;    thioureas;    antiproliferative activity;   

DOI  :  10.1590/S0103-50532006000500020

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12 and 16 were the most active with GI50 values in the range of 0.41 to 3.0 µmol L-1, against different cell lines.

【 授权许可】

Unknown