Molecules | |
Synthesis and Antiplatelet Activity of Antithrombotic Thiourea Compounds: Biological and Structure-Activity Relationship Studies | |
André Luiz Lourenço2  Max Seidy Saito2  Luís Eduardo Gomes Dorneles3  Gil Mendes Viana3  Plínio Cunha Sathler3  Lྫྷia Cruz de Sequeira Aguiar1  Marcelo de Pฝula3  Thaisa Francielle Souza Domingos3  Aline GuerraManssour Fraga3  Carlos Rangel Rodrigues4  Valeria Pereira de Sousa3  Helena Carla Castro5  Lucio Mendes Cabral3  | |
[1] Instituto de Química, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-909, RJ, Brazil; E-Mail:;Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24033-900, RJ, Brazil; E-Mails:;LabTIF, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-902, RJ, Brazil; E-Mails:;ModMolQSAR, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-902, RJ, Brazil; E-Mail:;LABiEMOL, Departamento de Biologia Celular e Molecular, Universidade Federal Fluminense (UFF), Niterói CEP 24033-900, RJ, Brazil | |
关键词:
thioureas;
antiplatelet properties;
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DOI : 10.3390/molecules20047174 | |
来源: mdpi | |
【 摘 要 】
The incidence of hematological disorders has increased steadily in Western countries despite the advances in drug development. The high expression of the multi-resistance protein 4 in patients with transitory aspirin resistance, points to the importance of finding new molecules, including those that are not affected by these proteins. In this work, we describe the synthesis and biological evaluation of a series of
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190013692ZK.pdf | 3703KB | download |