Regiospecific synthesis of new non-condensed heteropolycyclic systems from beta-heteroaryl-beta-methoxyvinyl trihalomethyl ketones

Journal of the Brazilian Chemical Society

Helio G. Bonacorso¹  Marlí R. Oliveira¹  Michelle B. Costa¹  Letícia B. Da Silva¹  Nilo Zanatta¹  Marcos A. P. Martins¹  Alex F. C. Flores¹ 

[1] ,Universidade Federal de Santa Maria Departamento de Química Santa Maria RS ,Brazil

关键词: 2-pyrazolines;    pyrazoles;    4-alkoxy-1;    1;    1-trihalo-alk-3-en-2-ones;    hydrazides;    heteroaroylhydrazines;    hydrazines;   

DOI  :  10.1590/S0103-50532005000500029

来源: SciELO

【 摘 要 】

A novel series of twelve heteroaroyl-2-pyrazolines trihalomethyl and substituted heteroaryl, as non-condensed heteropolycyclic systems, have been synthesized in one-step in 50-78% yield from the regiospecific cyclocondensation reaction of 1,1,1-trifluoro(chloro)-4-methoxy-4-(2-furyl)- and 4-(2-thienyl)-3-buten-2-ones (beta-alkoxyvinyl trihalometil ketones) with furoic hydrazide, 2-thiophenecarboxylic hydrazide and isonicotinic acid hydrazide (heteroaroylhydrazines) under mild conditions in methanol as solvent.

【 授权许可】

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