Regiospecific synthesis of new non-condensed heteropolycyclic systems from beta-heteroaryl-beta-methoxyvinyl trihalomethyl ketones

Journal of the Brazilian Chemical Society

Flores, Alex F. C.¹  Costa, Michelle B.¹  Zanatta, Nilo¹  Silva, Letícia B. da¹  Bonacorso, Helio G.¹  Martins, Marcos A. P.¹  Oliveira, Marlí R.¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: 2-pyrazolines;    pyrazoles;    4-alkoxy-1;    1;    1-trihalo-alk-3-en-2-ones;    hydrazides;    heteroaroylhydrazines;    hydrazines;   

DOI  :  10.1590/S0103-50532005000500029

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A novel series of twelve heteroaroyl-2-pyrazolines trihalomethyl and substituted heteroaryl, as non-condensed heteropolycyclic systems, have been synthesized in one-step in 50-78% yield from the regiospecific cyclocondensation reaction of 1,1,1-trifluoro(chloro)-4-methoxy-4-(2-furyl)- and 4-(2-thienyl)-3-buten-2-ones (b-alkoxyvinyl trihalometil ketones) with furoic hydrazide, 2-thiophenecarboxylic hydrazide and isonicotinic acid hydrazide (heteroaroylhydrazines) under mild conditions in methanol as solvent.

【 授权许可】

Unknown