Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity

Journal of the Brazilian Chemical Society

Fabiana V. Lima²  Angela Malheiros¹  Michel F. Otuki¹  João B. Calixto¹  Rosendo A. Yunes²  Valdir Cechinel Filho¹  Franco Delle Monache¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Quimica Florianópolis,Brazil

关键词: Protium kleinii;    Burseraceae;    pentacyclic triterpenes;    antinociceptive activity;   

DOI  :  10.1590/S0103-50532005000400014

来源: SciELO

【 摘 要 】

Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11beta,16beta-dihydroxy-urs-12-ene (1), 3-oxo-11beta-hydroxy-urs-12-ene (2) and 3-oxo-11beta-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3beta,16beta-dihydroxy-olean-12-ene (brein) (4) and a mixture of alpha (5)- and beta-amyrin (6) were also found.

【 授权许可】

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