Three new triterpenes from the resinous bark of Protium kleinii and their antinociceptive activity

Journal of the Brazilian Chemical Society

Calixto, João B.¹  Cechinel Filho, Valdir¹  Otuki, Michel F.¹  Università Cattolica, Roma, Italy¹  Yunes, Rosendo A.¹  Universidade Federal de Santa Catarina, Florianópolis, Brazil¹  Universidade do Vale do Itajaí, Itajaí, Brazil¹  Malheiros, Angela¹  Delle Monache, Franco¹  Lima, Fabiana V.¹ 

关键词: Protium kleinii;    Burseraceae;    pentacyclic triterpenes;    antinociceptive activity;   

DOI  :  10.1590/S0103-50532005000400014

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Three novel pentacyclic triterpenes have been isolated from the resin of Protium kleinii and their structures elucidated by NMR spectroscopy as 3-oxo-11b,16b-dihydroxy-urs-12-ene (1), 3-oxo-11b-hydroxy-urs-12-ene (2) and 3-oxo-11b-hydroxy-olean-12-ene (3). The systemic administration of the above compounds (10-100 mg kg-1, i.p.) was able to inhibited both first and second phase of the formalin-induced nociception in mice. The known triterpenes 3b,16b-dihydroxy-olean-12-ene (brein) (4) and a mixture of a (5)- and b-amyrin (6) were also found.

【 授权许可】

Unknown