Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells

Journal of the Brazilian Chemical Society

Grasiely Faria De Sousa²  Daniel Crístian Ferreira Soares¹  Wagner Da Nova Mussel²  Nana Flora Elias Pompeu²  Grácia Divina De Fátima Silva²  Sidney Augusto Vieira Filho¹  Lucienir Pains Duarte² 

[1] ,Universidade Federal de Minas Gerais Departamento de Química Belo Horizonte MG ,Brazil

关键词: Maytenus robusta;    Celastraceae;    pentacyclic triterpenes;    in vitro 4T1 cells cytotoxicity;   

DOI  :  10.5935/0103-5053.20140114

来源: SciELO

【 摘 要 】

Two new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.

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