Journal of the Brazilian Chemical Society | |
Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells | |
Grasiely Faria De Sousa2  Daniel Crístian Ferreira Soares1  Wagner Da Nova Mussel2  Nana Flora Elias Pompeu2  Grácia Divina De Fátima Silva2  Sidney Augusto Vieira Filho1  Lucienir Pains Duarte2  | |
[1] ,Universidade Federal de Minas Gerais Departamento de Química Belo Horizonte MG ,Brazil | |
关键词: Maytenus robusta; Celastraceae; pentacyclic triterpenes; in vitro 4T1 cells cytotoxicity; | |
DOI : 10.5935/0103-5053.20140114 | |
来源: SciELO | |
【 摘 要 】
Two new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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