Journal of the Brazilian Chemical Society | |
Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells | |
Silva, Grácia Divina de Fátima1  Pompeu, Nana Flora Elias1  Sousa, Grasiely Faria de1  Universidade Federal de Minas Gerais, Belo Horizonte, Brazil1  Soares, Daniel Crístian Ferreira1  Vieira Filho, Sidney Augusto1  Universidade Federal de Itajubá, Itabira, Brazil1  Universidade Federal de Ouro Preto, Ouro Preto, Brazil1  Duarte, Lucienir Pains1  Mussel, Wagner da Nova1  | |
关键词: Maytenus robusta; Celastraceae; pentacyclic triterpenes; in vitro 4T1 cells cytotoxicity; | |
DOI : 10.5935/0103-5053.20140114 | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
Two new friedelane-type compounds 1 and 2 and five known pentacyclic triterpenes were isolated from branches of Maytenus robusta. Their structures were identified as 3,16-dioxo-29-hydroxyfriedelane (1), 3-oxo-16b,29-dihydroxyfriedelane (2), 3-oxofriedelane (3), 3b-friedelinol (4), 3,16-dioxofriedelane (5), 3-oxo-29-hydroxyfriedelane (6), and 3,16-dioxo-12a-hydroxyfriedelane (7). The structures and the stereochemistry of triterpenes 1 and 2 were established through infrared (IR), 1D/2D nuclear magnetic resonance (NMR), high-resolution atmospheric pressure chemical ionization mass spectrometry (HR-APCIMS) spectral data and powder X-ray diffraction. The in vitro cytotoxic property of triterpenes 1 to 6 on 4T1 murine breast cancer cells was evaluated. The triterpenes 1 and 2 showed cytotoxic activity against 4T1 cells at a lower concentration.
【 授权许可】
Unknown
【 预 览 】
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RO201912050582241ZK.pdf | 300KB | download |