Chemical composition and antifungal activity of the essential oil of Hyptis ovalifolia Benth. (Lamiaceae)

Journal of the Brazilian Chemical Society

Cecília M. A. De Oliveira²  Maria Do Rosário R. Silva¹  Lucília Kato²  Cleuza C. Da Silva¹  Heleno D. Ferreira¹  Lúcia K. H. Souza¹ 

[1] ,Universidade Federal de Goiás Instituto de Química Goiânia GO ,Brazil

关键词: Hyptis ovalifolia;    essential oil;    antifungal activity;    Lamiaceae;    (R)-6-[(Z)-1-heptenyl]-5;    6-dihydro-2H-pyran-2-one;   

DOI  :  10.1590/S0103-50532004000500023

来源: SciELO

【 摘 要 】

The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fungi Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, and Tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration observed in the range of 125-7.8 mg µL-1.

【 授权许可】

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