Chemical composition and antifungal activity of the essential oil of Hyptis ovalifolia Benth. (Lamiaceae)

Journal of the Brazilian Chemical Society

Oliveira, Cecília M. A. de¹  Ferreira, Heleno D.¹  Souza, Lúcia K. H.¹  Silva, Cleuza C. da¹  Kato, Lucília¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Silva, Maria do Rosário R.¹  Universidade Federal de Maringá, Maringá, Brazil¹ 

关键词: Hyptis ovalifolia;    essential oil;    antifungal activity;    Lamiaceae;    (R)-6-[(Z)-1-heptenyl]-5;    6-dihydro-2H-pyran-2-one;   

DOI  :  10.1590/S0103-50532004000500023

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fungi Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, and Tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration observed in the range of 125-7.8 mg µL-1.

【 授权许可】

Unknown