The use of Fukuyama's sulfonamide in the synthesis of selectively protected spermidines

Journal of the Brazilian Chemical Society

Emerson T. Da Silva¹  Fátima S. Fona¹  Edson L. S. Lima¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Rio de Janeiro RJ ,Brazil

关键词: polyamines;    spermidine;    Fukuyama's sulfonamide;   

DOI  :  10.1590/S0103-50532004000300015

来源: SciELO

【 摘 要 】

The differentiation of terminal amino groups in polyamines usually involves a series of protection and deprotection steps, leading to long reaction sequences with low overall yields. Given the relevance of the biological activities displayed by polyamines, the development of more efficent synthetic routes for these compounds is highly desired. Herein we report the synthesis of two selectively protected spermidines, using Fukuyama's sulfonamide. Both syntheses were performed in three steps, starting from 1,3-diaminopropane, with an overall yield higher than 40%.

【 授权许可】

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