Rutin ameliorates methotrexate induced hepatic injury in rats

Acta Cirurgica Brasileira

Esra Erdogan¹  Yasin Ilgaz¹  Pinar Naile Gurgor¹  Yesim Oztas¹  Turgut Topal¹  Emin Oztas¹ 

关键词: Methotrexate;    Rutin;    Drug Effects;    Liver;    Rats;   

DOI  :  10.1590/S0102-865020150110000009

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats.METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum.RESULTS:Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups.CONCLUSION:Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.

【 授权许可】

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