Hyperoxic preconditioning in partial liver ischemia

Acta Cirurgica Brasileira

Maria Rita Margarido¹  Marina Rodrigues Garcia Da Silveira¹  José Carlos Vanni¹  Omar Feres¹  Orlando Castro-e-silva¹ 

关键词: Hyperbaric Oxygenation;    Mitochondria;    Liver;    Ischemia;    Reperfusion;    Rats;   

DOI  :  10.1590/S0102-86502014001300004

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of the hyperbaric oxygen (HBO) treatment as a pre-conditioning for I/R effects in the liver ischemia. METHODS: Fifty-seven male Wistar rats (260-300g) were submitted to the following procedures: SHAM; I/R, rats submitted to I/R, consisting of partial ischemia of 70% of the liver for 90 minutes followed by 15 minutes of reperfusion; HBO I/R 1 ATA, 30 minutes of HBO treatment at the pressure of 1 absolute atmosphere (ATA) during the ischemia time. HBO I/R 2 ATA, 30 minutes of HBO (2 ATA) during the ischemia time. Pre HBO I/R 30', rats submitted to 30 minutes of HBO (2 ATA) immediately before the I/R time. Pre HBO I/R 90', rats submitted to 90 minutes of HBO (2 ATA) immediately before the I/R time. RESULTS: There was a significant worsening of all the parameters of mitochondrial energy production (state 3, 4, RCR and Swelling) in the I/R group, when compared to the Sham group (I/R

【 授权许可】

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