Description of a new experimental model skin flap for studying skin viability in rats

Acta Cirurgica Brasileira

Cristina Pires Camargo¹  Nelson Fontana Margarido¹  Eduardo Guandelini¹  Guilherme Alexandre Barrucci Vieira¹  Alfredo Luiz Jacomo¹  Rolf Gemperli¹ 

关键词: Surgical Flaps;    Necrosis;    Models;    Animal;    Rats;   

DOI  :  10.1590/S0102-86502014000300004

来源: SciELO

【 摘 要 】

PURPOSE: To describe a new experimental flap for studying skin viability in rats.METHODS: Twenty male Wistar rats weighing between 250-300g were divided into two groups: group A - McFarlane technique, a 4 x 10cm flap was used (McFarlane); and in group B modified McFarlane technique, a 3 x 10cm flap was used. Seven days later, the animals were sacrificed and the area of necrosis was evaluated in both groups.RESULTS: Group A presented necrosis in 3% of the total area of the flap (CI: 0.01-0.05), Group B presented necrosis in 37% of the total area of the flap (CI: 0.29-0.46), (p<0.001).CONCLUSION: The modified McFarlane flap presented a larger area of necrosis and could be an adequate experimental model of skin flap viability.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License