Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits

Acta Cirurgica Brasileira

Cristian Durço Paço²  Matheus Fachini Vane¹  Rafael Bicarato De Andrade¹  Maria Aparecida Domingues¹  Lidia Raquel De Carvalho¹  Daniela Carvalho Dos Santos¹  Regina Kiomi Takahira¹  Norma Sueli Pinheiro Modolo¹  Luiz Antonio Vane¹ 

[1] ,Sao Paulo State University Botucatu Medical School Postgraduate Program in AnesthesiologyBotucatu SP ,Brazil

关键词: Anesthetics;    Intravenous;    Propofol;    Solvents;    Inflammation;    Microscopy;    Rabitts;   

DOI  :  10.1590/S0102-86502013001200005

来源: SciELO

【 摘 要 】

PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME). METHODS: Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM- surgical treatment alone; Bolus Control Group - 3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group - 3 mL- IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group - IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group - IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group - IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group - IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS: There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions. CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles. Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.

【 授权许可】

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