Acta Cirurgica Brasileira | |
Experimental model of cutaneous radiation injury in rabbits | |
Rafael Panisi De Campos Meirelles2  Bernardo Hochman1  Americo Helene Junior1  Rute Lellis1  Murillo Francisco Pires Fraga1  Lydia Masako Ferreira1  | |
[1] ,Federal University of Sao Paulo/Paulista School of Medicine (UNIFESP/EPM)Sao Paulo SP ,Brazil | |
关键词: Radiation Injuries; Radiotherapy Dosage; Models; Animal; Rabbits; | |
DOI : 10.1590/S0102-86502013001100001 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To describe an experimental model of cutaneous radiation injury in rabbits. METHODS: On this study eight six-month-old New Zealand male rabbits, with an average weight of 2.5kg were used. They were distributed in four groups (n=2 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 2000, 3000 and 4500 cGy, respectively. Photographic analysis and histopathological evaluation of the irradiated areas were carried out. RESULTS: After 30 days, the animals from the control group had all their hair grown. In spite of that, the animals from group 2000 cGy had a 60-day alopecia and from group 3000 cGy, a 90-day alopecia. After the 30th day, the 3000cGy group demonstrated 90-day cutaneous radiation injuries, graded 3 and 4. One of the animals from group 4500 cGy died on the 7th day with visceral necrosis. The other from the same group had total skin necrosis. A progressive reduction of glands and blood vessels count and an increase on collagen deposition was observed. CONCLUSION: The proposed experimental model is reproductable. This study suggests that the dosage 4500cGy is excessive and the 3000 cGy is the most effective for this experimental model of cutaneous radiation injury in rabbits.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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