Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

Acta Cirurgica Brasileira

Thamirys Guimarães Marques¹  Eleazar Chaib²  Juliana Hamati Da Fonseca¹  Ana Cecília Rodrigues Lourenço¹  Felipe Duarte Silva¹  Marcelo Augusto Fontenelle Ribeiro Jr¹  Flavio Henrique Ferreira Galvão¹  Luiz Augusto Carneiro D'albuquerque¹ 

[1] ,USP School of Medicine Department of GastroenterologySao Paulo,Brazil

关键词: Liver Cirrhosis;    Drugs;    Carbon Tetrachloride;    Common Bile Duct;    Ratos;    Cirrose Hepática;    Drogas;    Tetracloreto de Carbono;    Ducto Colédoco;    Ratos;   

DOI  :  10.1590/S0102-86502012000800013

来源: SciELO

【 摘 要 】

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

【 授权许可】

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