Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Acta Cirurgica Brasileira

Sônia Oliveira Lima²  Luciano Da Costa Viana¹  Fábio Rafael Teixeira De Santana¹  Ségio Zucoloto¹  Ricardo Luiz De Albuquerque Junior²  Margarete Zanardo Gomes² 

[1] ,Tiradentes UniversitySergipe,Brazil

关键词: Plants;    Medicinal;    Hepatectomy;    Proliferating Cell Nuclear Antigen;    Liver Regeneration;    Hyptis;    Rats;    Plantas Medicinais;    Hepatectomia;    Antígeno Nuclear de Célula em Proliferação;    Regeneração Hepática;    Hyptis;    Ratos;   

DOI  :  10.1590/S0102-86502012000100012

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS: Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS: The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION: These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.

【 授权许可】

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