Acta Cirurgica Brasileira | |
Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats | |
Sônia Oliveira Lima2  Luciano Da Costa Viana1  Fábio Rafael Teixeira De Santana1  Ségio Zucoloto1  Ricardo Luiz De Albuquerque Junior2  Margarete Zanardo Gomes2  | |
[1] ,Tiradentes UniversitySergipe,Brazil | |
关键词: Plants; Medicinal; Hepatectomy; Proliferating Cell Nuclear Antigen; Liver Regeneration; Hyptis; Rats; Plantas Medicinais; Hepatectomia; Antígeno Nuclear de Célula em Proliferação; Regeneração Hepática; Hyptis; Ratos; | |
DOI : 10.1590/S0102-86502012000100012 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS: Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS: The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION: These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130100655ZK.pdf | 697KB | download |