Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

Acta Cirurgica Brasileira

Vanessa Barreto Mourão¹  Gleice Mara Giraldi¹  Lia Mara Grosso Neves¹  Fernanda Oliveira De Gaspari De Gaspi¹  Rodney Alexandre Ferreira Rodrigues¹  Armindo Antonio Alves¹  Marcelo Augusto Marreto Esquisatto¹  Mauricio Ventura Mazzi¹  Fernanda Aparecida Sampaio Mendonça¹  Gláucia Maria Tech Dos Santos¹ 

关键词: Snake venons;    Plants;    Medicinal;    Mikania;    Bothrops;    Rats;   

DOI  :  10.1590/S0102-86502014000100005

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats.METHODS: Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4.RESULTS: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata.CONCLUSION: The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.

【 授权许可】

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