Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

Acta Cirurgica Brasileira

Cecília Maria De Carvalho Xavier Holanda²  Monique Batista Da Costa¹  Natália Chilinque Zambão Da Silva¹  Maurício Ferreira Da Silva Júnior¹  Vanessa Santos De Arruda Barbosa¹  Roseane Pereira Da Silva¹  Aldo Da Cunha Medeiros¹ 

[1] ,UFRN Department of Microbiology and Parasitology Head of Experimental Radiobiology and Antiparasitic Assays Laboratory,Brazil

关键词: Aloe;    Plants;    Medicinal;    Radioisotopes;    Sodium Pertechnetate Tc 99m;    Technetium;    Rats;    Aloe;    Plantas Medicinais;    Radioisótopos;    Pertecnetato Tc 99m de Sódio;    Tecnécio;    Ratos;   

DOI  :  10.1590/S0102-86502009000500008

来源: SciELO

【 摘 要 】

PURPOSE: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na99mTcO4 and laboratorial parameters in Wistar rats. METHODS: Twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na99mTcO4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (%ATI/g) was determined. Biochemical dosages were performed. RESULTS: There was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p<0.05). CONCLUSION: The aqueous extract of Aloe vera facilitated the uptake of Na99mTcO4 in organs of rats and it was responsible to a high increase of levels of AST and ALT.

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