Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney

Acta Cirurgica Brasileira

Fabio Geraldo Curtis²  Pedro Thadeu Galvão Vianna¹  Rosa Marlene Viero¹  Paulo Mateus Fiorio¹  Leopoldo Muniz Da Silva²  José Reinaldo Cerqueira Braz¹  Cristiano Oliveira¹  Yara Marcondes Machado Castiglia¹ 

[1] ,UNESP Botucatu Medical School Postgraduate Program in Anesthesiology,Brazil

关键词: Dexmedetomidine;    Kidney;    Reperfusion Injury;    Creatinine;    Necrosis;    Rats;    Dexmedetomidina;    Rim;    Traumatismo por Reperfusão;    Creatinina;    Necrose;    Ratos;   

DOI  :  10.1590/S0102-86502011000300008

来源: SciELO

【 摘 要 】

PURPOSE: To investigate blood creatinine and renal histology in rats anesthetized with S(+)-ketamine (keta) or dexmedetomidine (dex) and submitted to kidney ischemia/reperfusion injury (IRI). METHODS: Under intraperitoneal (ip) S(+)-ketamine, 20 male Wistar rats were divided into two groups (n=10): maintenance with iv S(+)-ketamine or dex (keta and dex groups), and submitted to right (R) nephrectomy and left (L) renal artery clamping for 45 min. Blood creatinine was measured before ischemia (T1) and 48h after reperfusion (T2), when L nephrectomy was performed. Histological analysis was performed in all kidneys. RESULTS: Blood creatinine was significantly higher at T2 in both groups, but dex group results were lower than those of keta group. Histological changes: between groups, R kidneys did not differ; there were significant high scores for vascular dilation: keta L kidneys; for vascular congestion, tubular dilation, and necrosis: L kidneys from both groups; for tubular degeneration: keta R kidneys. CONCLUSION: S(+)-ketamine plus IRI were aggressive to rat kidneys, according to histological changes, and dexmedetomidine may have not totally protected the kidneys from these injuries, despite the better results of blood creatinine.

【 授权许可】

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