The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury

Acta Cirurgica Brasileira

Devrim Tuglu¹  Ercan Yuvanc¹  Erdal Yılmaz¹  Isin Yazici Gencay¹  Pinar Atasoy¹  Ucler Kisa¹  Ertan Batislam¹ 

关键词: Dexmedetomidine;    Spermatic Cord Torsion;    Antioxidants;    Reperfusion Injury;    Testis;    Rats;   

DOI  :  10.1590/S0102-865020150060000007

来源: SciELO

【 摘 要 】

PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License