Acta Cirurgica Brasileira | |
Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice | |
Roberta Alves Higa1  Ricardo Dutra Aydos2  Iandara Schettert Silva2  Rondon Tosta Ramalho1  Albert Schiaveto De Souza1  | |
[1] ,UFMS Department of Surgery Campo Grande MS ,Brazil | |
关键词: Carcinogens; Colorectal Neoplasms; Azoxymethane; Tabebuia; Naphthoquinones; Mice; Carcinógenos; Neoplasias Colorretais; Azoximetano; Ipê-Roxo; Naftoquinonas; Camundongos; | |
DOI : 10.1590/S0102-86502011000200009 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.
【 授权许可】
CC BY
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