Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice

Acta Cirurgica Brasileira

Roberta Alves Higa¹  Ricardo Dutra Aydos²  Iandara Schettert Silva²  Rondon Tosta Ramalho¹  Albert Schiaveto De Souza¹ 

[1] ,UFMS Department of Surgery Campo Grande MS ,Brazil

关键词: Carcinogens;    Colorectal Neoplasms;    Azoxymethane;    Tabebuia;    Naphthoquinones;    Mice;    Carcinógenos;    Neoplasias Colorretais;    Azoximetano;    Ipê-Roxo;    Naftoquinonas;    Camundongos;   

DOI  :  10.1590/S0102-86502011000200009

来源: SciELO

【 摘 要 】

PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II - β-lapachone, in group III - vehicle (diluent) and in group IV - vehicle + AOM and finally in group V - β-lapachone + AOM. RESULTS: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. CONCLUSION: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License