Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test

Acta Cirurgica Brasileira

Honório Sampaio Menezes²  Bárbara Beatriz Moreira Bueno¹  Leandro Ciulla¹  Alexandre Schuh¹  Fernanda De Freitas Luz¹  Rafael José Vargas Alves¹  Milena Pacheco Abegg¹  Sílvia Letícia Merceo Bacchi Cirino¹ 

[1],Cardiology University Foundation IC Porto Alegre

关键词: Physiological Effects of Drugs;    Depression;    Animal Experimentation;    Rats;    Efeitos Fisiológicos de Drogas;    Depressão;    Experimentação Animal;    Ratos;   

DOI  :  10.1590/S0102-86502008000500010

来源: SciELO

【 摘 要 】

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.

【 授权许可】

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