Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test

Acta Cirurgica Brasileira

Leandro Ciulla¹  Honório Sampaio Menezes¹  Bárbara Beatriz Moreira Bueno¹  Alexandre Schuh¹  Rafael José Vargas Alves¹  Milena Pacheco Abegg¹ 

[1],ULBRACanoas RS ,Brazil

关键词: Physiological Effects of Drugs;    Fluoxetine;    Depression;    Animal Experimentation;    Efeitos Fisiológicos de Drogas;    Fluoxetina;    Depressão;    Experimentação Animal;   

DOI  :  10.1590/S0102-86502007000500005

来源: SciELO

【 摘 要 】

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.

【 授权许可】

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