Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism

Acta Cirurgica Brasileira

José Eduardo Aguilar-nascimento²  Sávio Prado¹  Geazi Zaffani¹  Alberto Bicudo Salomão¹  José De Souza Neves¹  Diana Borges Dock-nascimento¹  Paulo Roberto Bezerra De Mello¹  Thelma Suely Okay¹ 

[1] ,Federal University of Mato Grosso Medical School Department of Surgery

关键词: Probiotics;    Wound Healing;    Immunoglobulin A;    Immunity;    mucosal;    Anastomosis;    Surgical;    Colon;    Intestinal Mucosa;    Surgery;    Probióticos;    Cicatrização de feridas;    Imunoglobulina A;    Imunidade nas Mucosas;    Anastomose Cirúrgica;    Colo;    Mucosa Intestinal;    Cirurgia;   

DOI  :  10.1590/S0102-86502006001000017

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effects of perioperative administration of diet containing probiotics on the immune response, anastomotic resistance, and colonic mucosal trophism in rats underwent left-sided colonic anastomosis. METHODS: Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals each to receive or not a diet supplemented with probiotics (Streptococcus thermophilus e Lactobacillus helveticus) during pre- and postoperative period. They underwent laparotomy followed by left colon section and immediate anastomosis. Groups of 15 animals were killed either on the 4th (groups A1 and B1) or 7th PO (groups A2 and B2) days. The outcome variables were serum proteins, albumin, globulins and IgA, lenght and weight of the colon, mucosal weight, DNA content and anastomotic bursting pressure. RESULTS: Colonic weight was greater in probiotic group compared to controls (1,69±0,34g vs 1,48±0,26g; p<0.05). Total serum proteins and globulin were higher in probiotic animals (proteins = 7,05±0,97g/dl vs 6,57±0,66g/dl e globulins = 5,1±0,62g/dl vs 4,68±1,1g/dl; p<0.05). Serum IgA increased from basal to post-operative days only in the probiotic group (p<0.01). CONCLUSIONS: Perioperative probiotics enhanced the immune response and colonic weight. Probiotics failed to increase anastomotic resistance.

【 授权许可】

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