Experimental model to study the effect of nicotine in a random skin flap, in the rat

Acta Cirurgica Brasileira

Heitor Carvalho Gomes²  José Humberto Oliveira Campos¹  Lydia Masako Ferreira¹  Ludmila Aimi Kobayashi² 

[1],Federal University of São Paulo EPM

关键词: Surgical flaps;    Nicotine;    Tobacco;    Rats;    Retalhos cirúrgicos;    Nicotina;    Tabaco;    Ratos;   

DOI  :  10.1590/S0102-86502004000700012

来源: SciELO

【 摘 要 】

Presentation of an experimental model to study the effect of nicotine in a random skin flap, in the rat. Adult rats of the same lineage are exposed to nicotine for seven days in the preoperative period. After the preoperative period, the animals are anesthetized and a dorsal random pattern skin flap, cranially based is elevated. On the seventh postoperative day, the rats are anesthetized and the percentages of distal necrosis in the flaps are determined. After that, excision of skin fragments for biochemical analysis is possible. Blood samples may be collected by decapitation.

【 授权许可】

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