Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion

Revista Brasileira de Cirurgia Cardiovascular

Rafael Cantero Dorsa¹  José Carlos Dorsa Vieira Pontes¹  Andréia Conceição Brochado Antoniolli¹  Guilherme Viotto Rodrigues Da Silva¹  Ricardo Adala Benfatti¹  Carlos Henrique Marques Dos Santos¹  Elenir Rose Cury Pontes¹  José Anderson Souza Goldiano¹ 

关键词: Ischemia;    Reperfusion;    Ischemic Postconditioning;    Lung Injury;    Isquemia;    Reperfusão;    Pós-Condicionamento Isquêmico;    Lesão Pulmonar;   

DOI  :  10.5935/1678-9741.20150005

来源: SciELO

【 摘 要 】

AbstractObjective:To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Methods:Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.Results:GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).Conclusion:The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

【 授权许可】

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