Pantoprazole provides myocardial protection similar to ischemic preconditioning: experimental study of isolated hearts of rats

Revista Brasileira de Cirurgia Cardiovascular

Otoni Moreira Gomes²  Mônica De Mônico Magalhães¹  Rafael Diniz Abrantes¹  Elias Kallás¹ 

[1] ,Fundação Cardiovascular São Francisco de AssisBelo Horizonte MG ,Brazil

关键词: Ischemic preconditioning;    Myocardium;    Myocardial ischemia;    Myocardial infarction;    Precondicionamento isquêmico;    Miocárdio;    Isquemia miocárdica;    Infarto do miocárdio;   

DOI  :  10.5935/1678-9741.20110019

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate pantoprazole effect in the functional recovery of isolated hearts of rats, submitted to ischemia and reperfusion with and without ischemic preconditioning. METHODS: In four groups of eight Wistar breed rats, the hearts were removed after anesthesia and perfused with Krebs-Henseleit solution (95% O2, 5% CO2, 37ºC). GI, GII, GIII and GIV hearts were submitted to ischemia (20 min) and reperfusion (30 min). In GII and GIV, preconditioning was performed with 5 min of ischemia and 5 min of reperfusion before 20 min of the ischemia period induction. In GIII and GIV pantoprazole 100 mg was done before a 20 min-period of ischemia induction. Heart Rate (HR), Coronary Flow (CoF), Systolic Pressure (SP), +dP/dt and -dP/dt were registered before (t0) and after reperfusion (t30). Kruskal-Wallis (P<0.05) test was used. RESULTS: There were no differences (P>0.05) between groups among HR and CoF values. Differences occurred between groups, I and II, III and IV at t30 with SP reduced for 32% mean value in GI, 65% GII, 65% GIII, and 73% GIV; The t30 + dP/dtmax were 34% in GI, 61% GII, 63% GIII and 72% GIV. The t30 -dP/dtmax were GI 28%, GII 63%, GIII 75 % and GIV 75%; (P<0.05). There were no significant differences in the SP, +dP/dtmax, and -dP/dtmax between Groups II, III and IV results. CONCLUSIONS: The administration of pantoprazole before induction of ischemia significantly protected the myocardial functional recovery with the results of SP, + dP / dtmax and dP/dtmax similar to the ischemic preconditioning against ischemia-reperfusion

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