Metabolic and biological prospecting of Coreopsis tinctoria

Revista Brasileira de Farmacognosia

Luís Gaspar²  Andreia P. Oliveira²  Luís R. Silva¹  Paula B. Andrade²  Paula Guedes De Pinho¹  João Botelho²  Patrícia Valentão² 

[1] ,Universidade do Porto Faculdade de Farmácia Departamento de Química,Portugal

关键词: antibacterial;    antioxidant;    Coreopsis tinctoria;    fatty acids;    volatile compounds;   

DOI  :  10.1590/S0102-695X2011005000224

来源: SciELO

【 摘 要 】

Coreopsis tinctoria Nutt., Asteraceae, flowering tops infusion has been traditionally used in many countries to control hyperglycaemia. In this work we report for the first time fatty acids and volatile compounds in this species. Fifteen fatty acids and sixteen volatile compounds were determined by GC-ITMS, being saturated fatty acids and monoterpenes the main compounds. The antioxidant and antibacterial potential of this matrix was checked for the first time by several in vitro assays. A concentration-dependent activity was noticed against DPPH, nitric oxide and superoxide radicals. Antibacterial capacity was assessed against Gram-positive and Gram-negative bacteria, being more effective against the first. Additionally, acetylcholinesterase and butyrylcholinesterase inhibitory activity was also evaluated, but no effect was found. Our results provide evidence of a wide diversity of compounds with several biological properties, improving the knowledge on this poorly studied matrix, which can lead to an increment of the use of C. tinctoria flowering tops, namely in food and pharmaceutical applications.

【 授权许可】

CC BY-NC-ND   
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