Antioxidant effects of crude extracts from Baccharis species: inhibition of myeloperoxidase activity, protection against lipid peroxidation, and action as oxidative species scavenger

Revista Brasileira de Farmacognosia

Tiago O. Vieira²  Ilana Seifriz²  Carla C. T. Charão¹  Simone Q. De Oliveira²  Tânia B. Creczynski-pasa² 

[1] ,Universidade Federal de Santa Catarina Centro de Ciências da Saúde Departamento de Ciências Farmacêuticas,Brazil

关键词: antioxidant;    Bacharis;    carqueja;    lipid peroxidation;    myeloperoxidase;    peroxynitrite;   

DOI  :  10.1590/S0102-695X2011005000091

来源: SciELO

【 摘 要 】

The objective of this study was to show a comparison of the antioxidant properties of aqueous and ethanolic extracts obtained from Baccharis articulata (Lam.) Pers., Baccharis trimera (Less.) DC., Baccharis spicata (Lam.) Baill. and Baccharis usterii Heering, Asteraceae, by several techniques covering a range of oxidant species and of biotargets. We have investigated the ability of the plant extracts to scavenge DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical, action against lipid peroxidation of membranes including rat liver microsomes and soy bean phosphatidylcholine liposomes by ascorbyl radical and peroxynitrite. Hydroxyl radical scavenger activity was measured monitoring the deoxyribose oxidation. The hypochlorous acid scavenger activity was also evaluated by the prevention of protein carbonylation and finally the myeloperoxidase (MPO) activity inhibition. The results obtained suggest that the Baccharis extracts studied present a significant antioxidant activity scavenging free radicals and protecting biomolecules from the oxidation. We can suggest that the supposed therapeutic efficacy of this plant could be due, in part, to these properties.

【 授权许可】

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