Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage

Molecules

Maria Carla Marcotullio¹  Federica Messina¹  Massimo Curini¹  Antonio Macchiarulo¹  Marco Cellanetti¹  Donata Ricci¹  Laura Giamperi¹  Anahi Bucchini¹  Alba Minelli¹  Anna Lisa Mierla¹ 

[1] ¹Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, via del Liceo, 1-06123 Perugia, Italy

关键词: Commiphora erythraea (Burseraceae);    furanodienone;    lipid peroxidation;    5-LOX;    antioxidant;   

DOI  :  10.3390/molecules161210357

来源: mdpi

【 摘 要 】

By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC₅₀ of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.