Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora by GC/MS and their cholinesterase activity

Revista Brasileira de Farmacognosia

Lucie Cahlíková²  Irena Valterová¹  Kateřina Macáková²  Lubomír Opletal² 

[1] ,Charles University Faculty of Pharmacy Department of Pharmaceutical Botany and Ecology,Czech Republic

关键词: Amaryllidaceae;    acetylcholinesterase;    butyrylcholinesterase;    GC/MS;    Zephyranthes grandiflora;   

DOI  :  10.1590/S0102-695X2011005000089

来源: SciELO

【 摘 要 】

Amaryllidaceae are known as ornamental plants, furthermore some species of this family contain galanthamine, an acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, and other alkaloids with interesting pharmacological activity. The chemical composition of alkaloids from Zephyranthes grandiflora Lindl. was analyzed by GC/MS. Seven known compounds, belonging to five structural types of Amaryllidaceae alkaloids, were identified. The alkaloid extract from the bulbs showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50 39.2±3.0 µg/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 356±9.3 µg/mL).

【 授权许可】

CC BY-NC-ND   
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