Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora by GC/MS and their cholinesterase activity

Revista Brasileira de Farmacognosia

Cahlíková, Lucie¹  Valterová, Irena¹  Opletal, Lubomír¹  Charles University, Czech Republic¹  Institute of Organic Chemistry and Biochemistry of the AS CR, Czech Republic¹  Macáková, Kateřina¹ 

关键词: Amaryllidaceae;    acetylcholinesterase;    butyrylcholinesterase;    GC/MS;    Zephyranthes grandiflora;   

DOI  :  

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Amaryllidaceae are known as ornamental plants, furthermore some species of this family contain galanthamine, an acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, and other alkaloids with interesting pharmacological activity. The chemical composition of alkaloids from Zephyranthes grandiflora Lindl. was analyzed by GC/MS. Seven known compounds, belonging to five structural types of Amaryllidaceae alkaloids, were identified. The alkaloid extract from the bulbs showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50 39.2±3.0 µg/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 356±9.3 µg/mL).

【 授权许可】

Unknown