Antibacterial and cytotoxic properties of some plant crude extracts used in Northeastern folk medicine

Revista Brasileira de Farmacognosia

Suzana C. S. Ramos²  José C. S. De Oliveira¹  Cláudio A. G. Da Câmara¹  Ivan Castelar¹  Ana F. F. U. Carvalho¹  José V. Lima-filho² 

[1] ,Universidade Federal Rural de Pernambuco Departamento de Biologia Laboratório de Microbiologia e ImunologiaRecife PE ,Brazil

关键词: Artemia salina;    cytotoxicity;    antibacterial activity;    Croton;    Protium;    Muntingia calabura;    Artemia salina;    citotoxicidade;    atividade antibacteriana;    Croton;    Protium;    Muntingia calabura;   

DOI  :  10.1590/S0102-695X2009000300007

来源: SciELO

【 摘 要 】

In the present study, 32 hexane and ethanol extracts of Protium bahianum, P. heptaphyllum, Croton sellowii, C. rhamnifolius, C. jacobinensis, C. micans and Muntingia calabura were screened for antibacterial activity by the disc-diffusion method. Cytotoxicity assays using the brine shrimp Artemia salina Leach as a model were performed to determine lethal doses for 50% of individuals (LC50 µg/mL). Antibacterial activity was found in flowers hexane extracts of M. calabura against B. subtilis, and leaves ethanol extracts against S. aureus and B. subtilis at concentration of 1mg/mL. Among 32 extracts, 19 showed low or no toxicity (LC50 > 250 µg/mL), 6 showed moderate toxicity (LC50 between 80 µg/mL and 250µg/mL), and 7 were highly toxic (LC50 < 80 µg/mL).

【 授权许可】

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