Antibacterial and cytotoxic properties of some plant crude extracts used in Northeastern folk medicine

Revista Brasileira de Farmacognosia

Universidade Federal Rural de Pernambuco, Recife, Brazil¹  Ramos, Suzana C. S.¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Oliveira, José C. S. de¹  Câmara, Cláudio A. G. da¹  Carvalho, Ana F. F. U.¹  Lima-Filho, José V.¹  Castelar, Ivan¹ 

关键词: Artemia salina;    cytotoxicity;    antibacterial activity;    Croton;    Protium;    Muntingia calabura.;   

DOI  :  10.1590/S0102-695X2009000300007

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

In the present study, 32 hexane and ethanol extracts of Protium bahianum, P. heptaphyllum, Croton sellowii, C. rhamnifolius, C. jacobinensis, C. micans and Muntingia calabura were screened for antibacterial activity by the disc-diffusion method. Cytotoxicity assays using the brine shrimp Artemia salina Leach as a model were performed to determine lethal doses for 50% of individuals (LC50 µg/mL). Antibacterial activity was found in flowers hexane extracts of M. calabura against B. subtilis, and leaves ethanol extracts against S. aureus and B. subtilis at concentration of 1mg/mL. Among 32 extracts, 19 showed low or no toxicity (LC50 > 250 µg/mL), 6 showed moderate toxicity (LC50 between 80 µg/mL and 250µg/mL), and 7 were highly toxic (LC50 < 80 µg/mL).

【 授权许可】

Unknown