Concomitant chemopreventive and antibacterial effects of some Iranian plants from the genus Cousinia (Asteraceae)

Revista Brasileira de Farmacognosia

Ahmad Reza Shahverdi²  Mohammad Reza Khorramizadeh¹  Farideh Attar¹  Farshid Saadat¹  Sepideh Vahid²  Ahmad Ghahraman¹ 

[1] ,University of Tehran Faculty of Pharmacy, Medical Sciences Plant Research CentersTehran,Iran

关键词: Cousinia;    cytotoxicity;    IC50;    zymography;    antibacterial;    WEHI 164 cell line;    Cousinia;    citotoxicidade;    IC50;    zimografia;    antibacteriano;    linhagem celular WEHI 164;   

DOI  :  10.1590/S0102-695X2007000300004

来源: SciELO

【 摘 要 】

During the past several years, various species of Cousinia (Asteraceae) have been authenticated in Iran. However, data concerning their biological activities remain limited. The main purpose of this research was to assess potential cytotoxicity and matrix metalloproteinases (MMP) inhibitory effects of seven ethanol extracts of Cousinia using a cell line model (Fibrosarcoma-WEHI 164). We further investigated the antibacterial activity of these Cousinia ethanol extracts, using disk diffusion method. Among the ethanol extracts, the total extract of C. sulabadensis elicited significant inhibition of MMP activity in a dose-response fashion (49.2 ± 0.51, p < 0.05). However, this extract exhibited the lowest cytotoxicity effect at all tested concentrations. The concentration necessary to produce a 50% cell death rate (IC50) with C. shulabadensis was 304.5 ± 0.61 µg/mL. The calculated IC50 for cytotoxicity of the other Cousinia species extracts ranged between 18.4 ± 0.59 to 87.9 ± 0.58 µg/mL. The highest antibacterial activity was observed for the total extract of Cousinia phyllocephala. In conclusion, this study supports that Cousinia species display a remarkable inhibition of matrix metalloproteinases activity. The concomitant MMP-inhibitory and low cytotoxicity effects observed in C. sulabadensis might coin this extract for future potential anti-invasive herbal medicine studies.

【 授权许可】

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