Chrozophorin: a new acylated flavone glucoside from Chrozophora tinctoria (Euphorbiaceae)

Revista Brasileira de Farmacognosia

A. Delazar²  B. Talischi²  H. Nazemiyeh²  H. Rezazadeh²  L. Nahar¹  S.d. Sarker¹ 

[1] ,Tabriz University of Medical Sciences School of Pharmacy Drug Applied Research CenterTabriz,Iran

关键词: Chrozophora tinctoria;    Euphorbiaceae;    flavonoid;    flavone;    glycoside;    quercetin;    apigenin;    rutin;    chrozophorin;    DPPH;    Chrozophora tinctoria;    Euphorbiaceae;    flavonóide;    flavona;    glicosídeo;    quercetina;    apigenina;    rutina;    crozoforina;    DPPH;   

DOI  :  10.1590/S0102-695X2006000300002

来源: SciELO

【 摘 要 】

Preparative reversed-phase HPLC analysis of the methanol extract of the aerial parts of Chrozophora tinctoria (Euphorbiaceae) yielded five flavonoid glycosides, quercetin 3-O-rutinoside (1, rutin), acacetin 7-O-rutinoside (2), apigenin 7-O-b-D-[(6-p-coumaroyl)]-glucopyranoside (3), apigenin 7-O- b-D-glucopyranoside (4) and apigenin 7-O-b-D-[6-(3,4-dihydroxybenzoyl)]-glucopyranoside (named, chrozophorin, 5), the last one being a new natural product. The structures of these compounds were elucidated unambiguously by UV spectroscopic analyses using shift reagents, ESIMS, and 1D and 2D NMR spectroscopic techniques. The free-radical scavenging activity of the methanol extract (RC50 = 2.24 x 10-1 mg/mL) as well as the isolated compounds (1-5) (RC50 = 4.38 x 10-3, 2.26 x 10-2, 7.69 x 10-4, 8.71 x 10-3 and 3.19 x 10-4 mg/mL, respectively) were assessed by the DPPH assay.

【 授权许可】

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