Natural products inhibitors of the enzyme acetylcholinesterase

Revista Brasileira de Farmacognosia

José M. Barbosa Filho²  Karina C. Paula Medeiros²  Margareth De Fátima F.m. Diniz²  Leônia M. Batista²  Petrônio F. Athayde-filho²  Marcelo S. Silva²  Emídio V.l. Da Cunha²  Jackson R.g. Silva Almeida¹  Lucindo J. Quintans-júnior¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica ‘Delby Fernandes de Medeiros’ João Pessoa PB ,Brazil

关键词: Acetylcholinesterase inhibitors;    AChE;    Alzheimer's disease;    neurodegenerative disorders;    medicinal plants;    natural products;    review;    Inibidores da Acetilcolinesterase;    AchE;    doença de Alzheimer;    distúrbios neurodegenetivos;    plantas medicinais;    produtos naturais;    revisão;   

DOI  :  10.1590/S0102-695X2006000200021

来源: SciELO

【 摘 要 】

Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily affects the elderly population, and is estimated to account for 50-60% of dementia cases in persons over 65 years of age. The main symptoms associated with AD involve cognitive dysfunction, primarily memory loss. Other features associated with the later stages of AD include language deficits, depression, behavioural problems including agitation, mood disturbances and psychosis. One of the most promising approaches for treating this disease is to enhance the acetylcholine level in the brain using acetylcholinesterase (AChE) inhibitors. The present work reviews the literature on plants and plant-derived compounds inhibitors of enzyme acetylcholinesterase. The review refers to 309 plant extracts and 260 compounds isolated from plants, which are classified in appropriate chemical groups and model tested, and cites their activity. For this purpose 175 references were consulted.

【 授权许可】

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