Impact of highly active antiretroviral therapy (HAART) on the incidence of opportunistic infections, hospitalizations and mortality among children and adolescents living with HIV/AIDS in Belo Horizonte, Minas Gerais State, Brazil

Cadernos de Saúde Pública

Talitah M. S. Candiani²  Jorge Pinto²  Claudete A. Araújo Cardoso²  Inácio R. Carvalho²  Arlete C. M. Dias²  Mariângela Carneiro²  Eugênio A. Goulart¹ 

[1] ,Universidade Federal de Minas Gerais Hospital das Clínicas Belo Horizonte,Brasil

关键词: Highly Active Antiretroviral Therapy;    Oppurtunist Infections;    HIV;    Terapia Anti-Retroviral de Alta Atividade;    Infecções Oportunistas;    HIV;   

DOI  :  10.1590/S0102-311X2007001500009

来源: SciELO

【 摘 要 】

The impact of highly active antiretroviral therapy (HAART) can be evaluated using indicators, such as rates of opportunistic infections, hospitalizations by cause of infection, and associated death. This study aimed to estimate the impact of HAART on the incidence of these indicators, in children and adolescents with HIV/AIDS. It was a hybrid cohort study; 371 patients were followed from 1989 to 2003. In December 2003, 76% of the patients were still being followed, while 12.1% had died, 9.5% had dropped out, and 2.4% had been transferred. The overall rate of opportunistic infections was 18.32 infections/100 persons-year and 2.63 in the pre- and post-HAART periods, respectively. In the multivariate analysis, the risk of developing an opportunistic infection was 5.4 times greater and 3.3 times greater for hospitalization risk before HAART. Respiratory causes represented 65% of the hospitalizations and they were reduced by 44.6% with therapeutic intervention. The average hospital stay of 15 days was reduced to 9.There was a post-HAART decline in deaths of 38%. This study demonstrates the effectiveness of HAART in significantly reducing opportunistic infections, hospitalizations, and deaths in this Brazilian cohort.

【 授权许可】

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