The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis

Brazilian Journal of Medical and Biological Research

S.n. Slavov¹  H.l. Gimenes Teixeira¹  E.m. Rego¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto e Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular Departamento de Clínica MédicaRibeirão Preto SP ,Brasil

关键词: MicroRNAs;    Gene expression;    Leukemia;    Acute lymphoblastic leukemia;    T cells;   

DOI  :  10.1590/S0100-879X2010007500057

来源: SciELO

【 摘 要 】

Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.

【 授权许可】

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