Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Brazilian Journal of Medical and Biological Research

C.m. Baratti¹  M.m. Boccia¹  M.g. Blake¹ 

[1] ,Universidad de Buenos Aires Facultad de Farmacia y Bioquímica Cátedra de FarmacologíaBuenos Aires,Argentina

关键词: Memory;    Consolidation;    Reconsolidation;    Extinction;    Inhibitory avoidance;   

DOI  :  10.1590/S0100-879X2009000200001

来源: SciELO

【 摘 要 】

In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".

【 授权许可】

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