Understanding the dynamic and destiny of memories

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:125

Review

Alvares, Lucas de Oliveira¹  Do-Monte, Fabricio H.² 

[1] Univ Fed Rio Grande do Sul, Biophys Dept, Biosci Inst, Neurobiol Memory Lab, BR-91509900 Porto Alegre, RS, Brazil

[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurobiol & Anat, Houston, TX 77030 USA

关键词: Memory updating;    Reconsolidation;    Extinction;    Forgetting;    Retrieval;   

DOI  :  10.1016/j.neubiorev.2021.03.009

来源: Elsevier

【 摘 要 】

Memory formation enables the retention of life experiences overtime. Based on previously acquired information, organisms can anticipate future events and adjust their behaviors to maximize survival. However, in an everchanging environment, a memory needs to be malleable to maintain its relevance. In fact, substantial evidence suggests that a consolidated memory can become labile and susceptible to modifications after being reactivated, a process termed reconsolidation. When an extinction process takes place, a memory can also be temporarily inhibited by a second memory that carries information with opposite meaning. In addition, a memory can fade and lose its significance in a process known as forgetting. Thus, following retrieval, new life experiences can be integrated with the original memory trace to maintain its predictive value. In this review, we explore the determining factors that regulate the fate of a memory after its reactivation. We focus on three postretrieval memory destinies (reconsolidation, extinction, and forgetting) and discuss recent rodent studies investigating the biological functions and neural mechanisms underlying each of these processes.

【 授权许可】

Free