Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities

Brazilian Journal of Medical and Biological Research

C. Petit¹  V. Bernardes-genisson¹  P. Hoffmann¹  J.-p. Souchard¹  S. Labidalle¹ 

[1] ,Faculté des Sciences PharmaceutiquesToulouse,France

关键词: nitric oxide;    S-nitrosothiols (thionitrites);    antioxidant;    peroxynitrite;   

DOI  :  10.1590/S0100-879X1999001100011

来源: SciELO

【 摘 要 】

Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM.

【 授权许可】

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