期刊论文详细信息
Brazilian Journal of Medical and Biological Research
Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system
K.m. Lima1  J.m. Rodrigues Júnior1 
[1] ,Universidade Federal de Minas Gerais
关键词: vaccine;    adjuvant;    microspheres;    microencapsulation;    biomaterial;   
DOI  :  10.1590/S0100-879X1999000200005
来源: SciELO
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【 摘 要 】

Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of administration. The development of controlled release systems based on polymeric devices that permit a sustained or pulsed release of encapsulated antigens has attracted much interest. Polymeric delivery systems consist of polymers that release their content continuously in a controlled manner over a period of time. The development of a biocompatible delivery system for parenteral administration offers several advantages in terms of immunoadjuvanticity over other compounds. It was found that, in contrast to other carriers, microspheres are more stable, thus permitting administration by the oral or parenteral route. In the present study, we describe the main characteristics and potentialities of this new immunoadjuvant for oral and parenteral administration.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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