Journal of Functional Biomaterials | |
Caffeic Acid-PLGA Conjugate to Design Protein Drug Delivery Systems Stable to Irradiation | |
Francesca Selmin1  Francesco Puoci2  Ortensia I. Parisi2  Silvia Franzé1  Umberto M. Musazzi1  Francesco Cilurzo1  | |
[1]Università degli Studi di Milano, Department of Pharmaceutical Sciences—via Giuseppe Colombo, 71-20133 Milano, Italy | |
[2] E-Mails: | |
[3]Università degli Studi della Calabria, Department of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, Italy | |
[4] E-Mails: | |
关键词: anti-oxidant; microencapsulation; drug release; caffeic acid; grafting; γ-irradiation; microspheres; ovalbumin; poly(lactide-co-glycolide); sterilization; | |
DOI : 10.3390/jfb6010001 | |
来源: mdpi | |
【 摘 要 】
This work reports the feasibility of caffeic acid grafted PLGA (g-CA-PLGA) to design biodegradable sterile microspheres for the delivery of proteins. Ovalbumin (OVA) was selected as model compound because of its sensitiveness of γ-radiation. The adopted grafting procedure allowed us to obtain a material with good free radical scavenging properties, without a significant modification of
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190017856ZK.pdf | 434KB | download |